Two quick fire goals early on in the second half were enough for Bayern Munich to brush aside Barcelona at the Alianz Arena.
Lewandowski returned to Germany hoping to continue with his free scoring spree that he has started life in Spain with, but him and his teammates were upstaged by Julian Nagelsmann.
A game that was billed to be a tough encounter ended up being a one-sided affair as the Bavarians pegged them back with two goals in four minutes.
First it was Lucas Hernandez, who nodded in a swirling Joshua Kimmich corner after Raphinha completely misjudged the pace of the ball.
Shortly after that Bayern doubled their lead. Jamal Musiala fed Leroy Sane through the smallest of openings through the Barcelona defence and the former Manchester City winger made no mistakes from there.
From there on, Barcelona turned off and were unable to find themselves back into the game.
Bayern now sit top of Group C. In the last four meetings between these two, Bayern have scored 16 goals and Barcelona have scored only 2.